Conclusions: Immunohistochemistry can make significant contributions to the diagnosis of sebaceous carcinoma.

Purpose: To evaluate the fine cytopathologic features and immunohistochemistry of eyelid sebaceous carcinoma.

This report supports prospective clinical trials of anti-PD1 checkpoint blockade for metastatic sebaceous carcinoma.

Methods: Clinical records and microscopic glass slides of 12 patients diagnosed with sebaceous carcinoma were reviewed.

Histologically, the tumor was diagnosed as sebaceous carcinoma.